Cas No. |
Product name |
162635-04-3 |
Temsirolimus(CCI-779) |
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Temsirolimus (also known as CCI-779) is a recently developed mTOR inhibitor. |
677338-12-4 |
PIK-90 |
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PIK-90 is a PI3Kα/γ/δ inhibitor with IC50 of 11 nM/18 nM/58 nM, respectively, less potent to PI3Kβ(IC50= 350 nM). |
955977-50-1 |
PI-3065 |
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PI-3065 is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR. |
1033735-94-2 |
GNE-493 |
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GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively. |
475110-96-4 |
ZSTK-474 |
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ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM, mostly PI3Kδ. Phase1/2. |
870281-34-8 |
Acalisib (GS-9820) |
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Acalisib, also known as GS-9820, is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential ... |
221877-54-9 |
Zotarolimus(ABT-578) |
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Zotarolimus (ABT-578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM. |
572924-54-0 |
Deforolimus |
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Deforolimus(AP23573; MK-8669; Ridaforolimus) is a selective mTOR inhibitor with IC50 of 0.2 nM; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is simil... |
326914-06-1 |
MHY1485 |
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MHY1485 is a mTOR activator; inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enl... |
1394076-92-6 |
GNE-317 |
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GNE-317 is a potent PI3K/mTOR inhibitor that can cross the blood–brain barrier; shows potent suppression of the PI3K pathway in the brain of mice with intact BBB. |