Ivosidenib ID:1523
Synonyms: |
CAS NO : 1448346-63-1 |
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Molecular Formula: C28H22ClF3N6O3 |
Molecular Weight: 582.97 |
Purity: 98% |
Solubility: In DMSO |
Storage: -20°C |
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Remarks:Ivosidenib is also konw as AG120; AG 120; AG-120; an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells.
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H-NMR,C-NMR,LC-MS,HPLC. |
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