CC-115 ID:1576
| Synonyms: |
| CAS NO : 1228013-15-7 |
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| Molecular Formula: C16H16N8O |
| Molecular Weight: 336.14 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC-115 binds to and inhibits the activity of DNA-PK and both raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK and TOR. DNA-PK, a serine/threonine kinase and a member of the PI3K-related kinase subfamily of protein kinases, is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks via the DNA nonhomologous end joining (NHEJ) pathway.
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H-NMR,C-NMR,LC-MS,HPLC. |
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