CEP33779 ID:1580
| Synonyms: |
| CAS NO : 1257704-57-6 |
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| Molecular Formula: C24H26N6O2S |
| Molecular Weight: 462.57 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:CEP-33779 is a highly selective, orally active, small-molecule inhibitor of JAK2. CEP-33779 induced regression of established colorectal tumors, reduced angiogenesis, and reduced proliferation of tumor cells. Tumor regression correlated with inhibition of STAT3 and NF-κB (RelA/p65) activation in a CEP-33779 dose-dependent manner. The ability of CEP-33779 to suppress growth of colorectal tumors by inhibiting the IL-6/JAK2/STAT3 signaling suggests a potential therapeutic utility of JAK2 inhibitors in multiple tumors types, particularly those with a strong inflammatory component.
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H-NMR,C-NMR,LC-MS,HPLC. |
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