Alanosine ID:1528
| Synonyms: |
| CAS NO : 5854-93-3 |
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| Molecular Formula: C3H7N3O4 |
| Molecular Weight: 149.11 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:Alanosine, also known as L-alanosine, is an amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities. L-alanosine inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate, an intermediate in purine metabolism. L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. The clinical use of this agent may be limited by its toxicity profile. MTAP is a key enzyme in the adenine and methionine salvage pathways.
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H-NMR,C-NMR,LC-MS,HPLC. |
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