KPT-330 ID:1649
| Synonyms: |
| CAS NO : 1421923-86-5 |
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| Molecular Formula: C17H11F6N7O |
| Molecular Weight: 443.31 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:KPT-330 inhibited proliferation and induced cell cycle arrest and apoptosis-related proteins in 11 NSCLC cells lines. Moreover, the combination of KPT-330 with cisplatin synergistically enhanced the cell kill of the NSCLC cells in vitro. Human NSCLC tumours growing in immunodeficient mice were markedly inhibited by KPT-330. Also, KPT-330 was effective even against NSCLC cells with a transforming mutation of either exon 20 of EGFR, TP53, phosphatase and tensin homologue, RAS or PIK3CA, suggesting the drug might be effective against a variety of lung cancers irrespective of their driver mutation.
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