BMS-790052 ID:1595
Synonyms: |
CAS NO : 1214735-16-6 |
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Molecular Formula: C40H50N8O6 |
Molecular Weight: 738.88 |
Purity: 98% |
Solubility: In DMSO |
Storage: -20°C |
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Remarks:BMS-790052 is a first-in-class, highly selective inhibitor of hepatitis C virus (HCV) NS5A with an EC50 of 9–50 pM. BMS-790052 is one of the most potent inhibitors of HCV replication reported so far. The mean EC50 values of BMS-790052 are 50 and 9 pM for HCV genotype 1a and 1b replicons, respectively. BMS-790052 displays a therapeutic index (CC50/EC50) of at least 105 and is inactive towards a panel of 10 RNA and DNA viruses, with EC50 higher than 10 μM. This confirms BMS-790052's specificity for HCV. In Huh7 cells harboring the HCV genotype 1b replicons, BMS-790052 blocks both transient and stable HCV genome replication, with EC50 values raging from 1–15 pM. BMS-790052 (100 pM or 1 nM) has been shown to alter the subcellular localization and biochemical fractionation of NS5A. BMS-790052 inhibits hybrid replicons containing HCV genotype-4 NS5A genes with EC50 of 7–13 pM. Residue 30 of NS5A is an important site for BMS-790052-mediated resistance in the hybrid replicons.
Quality Control
H-NMR,C-NMR,LC-MS,HPLC. |
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