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Products - Others - GSK591
GSK591  ID:1628
CAS NO : 1616391-87-7
Molecular Formula: C22H28N4O2
Molecular Weight: 380.492
Purity: 98%
Solubility: In DMSO
Storage: -20°C
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Remarks:GSK591, also known as EPZ015866, is a chemical probe for PRMT5. In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z-138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases.
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