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GSK591 ID:1628
| Synonyms: |
| CAS NO : 1616391-87-7 |
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| Molecular Formula: C22H28N4O2 |
| Molecular Weight: 380.492 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:GSK591, also known as EPZ015866, is a chemical probe for PRMT5. In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z-138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases.
Quality Control
H-NMR,C-NMR,LC-MS,HPLC. |
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Disclaimer |
If the compound involving patent protection, do not for commercial purposes, for research use only. If being sold to countries constitute patent infringement, then everything will be corresponding risk buyer.
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