ARRY-543 ID:1538
| Synonyms: |
| CAS NO : 114629-86-8 |
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| Molecular Formula: C22H19ClN6O2S |
| Molecular Weight: 466.951 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:ARRY-543 is also know as a novel, oral ErbB family inhibitor that, unlike approved ErbB inhibitors, targets all members of the ErbB family, including ErbB3, either directly or indirectly, and has potential advantages in treating tumors that signal through multiple ErbB family members. In early clinical trials, monotherapy with ARRY-543 has shown clinical benefit in several tumor types, including ErbB2 positive metastatic breast cancer and EGFR expressing cholangiocarcinoma, with a generally favorable tolerability and pharmacokinetic profile. In preclinical studies, ARRY-543 was shown to be superior to an approved ErbB inhibitor in tumors that signal through multiple ErbB family members.
Quality Control
H-NMR,C-NMR,LC-MS,HPLC. |
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