BMS-911543 ID:1572
| Synonyms: |
| CAS NO : 1271022-90-2 |
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| Molecular Formula: C23H28N8O |
| Molecular Weight: 432.52142 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. JAK2 inhibitor BMS-911543 selectively inhibits JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent.
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H-NMR,C-NMR,LC-MS,HPLC. |
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