Cas No. |
Product name |
663619-89-4 |
TGX221 |
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TGX-221 is a p110β-specific inhibitor with IC50 of 5 nM, 1000-fold more selective for p110β than p110α. |
1372540-25-4 |
GSK2636771 |
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GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor, sensitive to PTEN null cell lines. Phase 1/2a. |
957054-30-7 |
GDC0941 |
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GDC-0941 is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). |
1086062-66-9 |
GSK2126458(GSK458) |
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GSK2126458 is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM, respectively. Phase 1. |
1144068-46-1 |
WYE125132(WYE-132) |
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WYE-125132 is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR. |
53123-88-9 |
Rapamicin(sirolimus ) |
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Rapamycin is antifungal and immunosuppressant and specific inhibitor of mTOR (mammalian target of Rapamycin). Complexes with FKBP-12 and binds mTOR inhibiting its activity. R... |
593960-11-3 |
PIK93 |
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PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM. |
1345675-02-6 |
ETP46464 |
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ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM. |
1276110-06-5 |
HS-173 |
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HS-173 is a potent PI3Kα inhibitor with IC50 of 0.8 nM. |
956958-53-5 |
XL147 |
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XL147 is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM, less potent to PI3Kβ. Phase 1/2. |