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Cas No. |
Product name |
935881-37-1 |
AR-42 |
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AR-42 is an HDAC inhibitor with IC50 of 30 nM |
726169-73-9 |
Mocetinostat (MGCD0103) |
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Mocetinostat (MGCD0103) is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM, 2- to 10- fold selectivity against HDAC2, 3, and 11, and no activity to H... |
779353-01-4 |
Dinaciclib (SCH727965) |
more... |
Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively. It also blocks thymidine (dThd)... |
802539-81-7 |
PHA-848125 |
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PHA-848125 is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7. Phase 2. |
827022-32-2 |
Palbociclib (PD-0332991) HCl |
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PD0332991 is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3. |
920113-03-7 |
P276-00 |
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p276-00 is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. |
891494-63-6 |
MK-8776 (SCH 900776)(S) |
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SCH 900776 is a selective Chk1 inhibitor with IC50 of 3 nM. It shows 500-fold selectivity against Chk2. Phase 2. |
1211441-98-3 |
Ribociclib (LEE011) |
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LEE011 is an orally available, and highly specific CDK4/6 inhibitor. |
934541-31-8 |
TAK901 |
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TAK-901 is a novel inhibitor of Aurora A/B with IC50 of 21 nM/15 nM. It is not a potent inhibitor of cellular JAK2, c-Src or Abl. Phase 1. |
602306-29-6 |
AZD5438 |
more... |
AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM. It is less potent to CDK5/6 and also inhibits GSK3β. Phase 1. |
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