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Cas No. |
Product name |
1094614-85-3 |
BIX02189 |
more... |
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM, and does not inhibit closely related kinases MEK1, ME... |
1011557-82-6 |
Tenovin-6 |
more... |
Tenovin-6 is a small molecule activator of p53 transcriptional activity. |
881202-45-5 |
JNJ26854165 |
more... |
JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by dela... |
71555-25-4 |
NSC319726 |
more... |
NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wi... |
923564-51-6 |
ABT-263 (Navitoclax) |
more... |
ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM, but binds more weakly to Mcl-1 and A1. Phase 2. |
1257044-40-8 |
ABT-199 (GDC-0199) |
more... |
ABT-199 (GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Phase 3. |
852808-04-9 |
ABT737 |
more... |
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. ... |
877877-35-5 |
TW-37 |
more... |
TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively. |
65673-63-4 |
HA14-1 |
more... |
HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM. |
213261-59-7 |
RITA (NSC 652287) |
more... |
RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53. |
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