Cas No. |
Product name |
371942-69-7 |
YM201636 |
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YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α and insensitive to Fabl (yeast orthologue). |
159351-69-6 |
Everolimus (RAD001) |
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Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM. |
936890-98-1 |
OSI027 |
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OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI... |
162635-04-3 |
Temsirolimus(CCI-779) |
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Temsirolimus (also known as CCI-779) is a recently developed mTOR inhibitor. |
677338-12-4 |
PIK-90 |
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PIK-90 is a PI3Kα/γ/δ inhibitor with IC50 of 11 nM/18 nM/58 nM, respectively, less potent to PI3Kβ(IC50= 350 nM). |
955977-50-1 |
PI-3065 |
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PI-3065 is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR. |
1033735-94-2 |
GNE-493 |
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GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively. |
475110-96-4 |
ZSTK-474 |
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ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM, mostly PI3Kδ. Phase1/2. |
870281-34-8 |
Acalisib (GS-9820) |
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Acalisib, also known as GS-9820, is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential ... |
221877-54-9 |
Zotarolimus(ABT-578) |
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Zotarolimus (ABT-578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM. |