CNX-1351 ID:433
| Synonyms: |
| CAS NO : 1276105-89-5 |
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| Molecular Formula: C30H35N7O3S |
| Molecular Weight: 573.71 |
| Purity: 98% min |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:CNX-1351 is a selective covalent Inhibitor of PI3Kα. CNX-1351 was tested against all four of the class I PI3K enzymes α, β, γ, and δ. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20−400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α
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