AZD-5069 ID:1548
| Synonyms: |
| CAS NO : 878385-84-3 |
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| Molecular Formula: C18H22F2N4O5S2 |
| Molecular Weight: 476.51 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:AZD-5069 is a potent and selective CXCR2 antagonist with the potential to inhibit neutrophil migration into the airways in patients with COPD. AZD-5069 was shown to inhibit binding of radiolabeled CXCL8 to human CXCR2 with a pIC50 value of 9.1. Furthermore, AZD5069 inhibited neutrophil chemotaxis, with a pA2 of approximately 9.6, and adhesion molecule expression, with a pA2 of 6.9, in response to CXCL1. AZD5069 was a slowly reversible antagonist of CXCR2 with effects of time and temperature evident on the pharmacology and binding kinetics. AZD-5069 is also potential useful for patient in inflammatory conditions.
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