AMG-837 calcium salt hydrate ID:1531
Synonyms: |
CAS NO : 1259389-38-2 |
|
Molecular Formula: C52H42CaF6O7 |
Molecular Weight: 932.9694 |
Purity: 98% |
Solubility: In DMSO |
Storage: -20°C |
Availability and Price
|
If the item is temporarily out of stock. Please email to sales@betterbiochem.com,we will inform you when we have it in stock. |
In Stock |
|
Order |
Remarks:AMG-837 is also konw as AMG837; AMG-837; AMG 837,a potent, orally bioavailable GPR40 agonist. AMG 837 was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Acute administration of AMG 837 lowered glucose excursions and increased glucose stimulated insulin secretion during glucose tolerance tests in both normal and Zucker fatty rats. The improvement in glucose excursions persisted following daily dosing of AMG 837 for 21-days in Zucker fatty rats. Preclinical studies demonstrated that AMG 837 was a potent GPR40 partial agonist which lowered post-prandial glucose levels. These studies support the potential utility of AMG 837 for the treatment of type 2 diabetes.
Quality Control
H-NMR,C-NMR,LC-MS,HPLC. |
|
Related Products
Others
|