AC 710 ID:1515
| Synonyms: |
| CAS NO : 1351522-04-7 |
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| Molecular Formula: C31H42N6O4 |
| Molecular Weight: 562.7 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:
N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide;
Potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.
Quality Control
H-NMR,C-NMR,LC-MS,HPLC. |
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