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Cas No. |
Product name |
606143-89-9 |
Binimetinib(MEK162) |
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MEK162(ARRY-438162; ARRY-162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM. |
1168091-68-6 |
GDC-0623 |
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GDC-0623 is a potent, ATP-uncompetitive inhibitors of MEK1(Ki=0.13 nM, +ATP); 6-fold weaker potency against HCT116 (KRAS(G13D), EC50=42 nM) versus A375 (BRAF(V600E), EC50=7 n... |
212631-79-3 |
PD184352 |
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CI-1040 is a selective MEK inhibitor (Ki = 300 nM in vitro). CI-1040 suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic effi... |
72873-74-6 |
SKF-86002 |
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SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). |
193551-21-2 |
SB 239063 |
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SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more s... |
934660-93-2 |
Cobimetinib (GDC-0973, RG7420) |
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Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2). |
874101-00-5 |
RO4987655 (CH-4987655) |
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RO4987655 (CH-4987655) is an orally active inhibitors of MAP2K1/MEK1, the IC50 for 5.2 nM, with antitumor activity. |
303162-79-0 |
TAK-715 |
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TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1 |
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