LGK974 (WNT974) ID:1654
| Synonyms: |
| CAS NO : 1243244-14-5 |
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| Molecular Formula: C23H20N6O |
| Molecular Weight: 396.44 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks: LGK974, aslo known as is a selective and orally bioavailable Porcupine (PORCN) inhibitor under development for the treatment of cancers that are driven by the Wnt pathway in a Wnt ligand-dependent manner. WNT974 binds to and inhibits PORCN in the endoplasmic reticulum (ER), which blocks post-translational acylation of Wnt ligands and inhibits their secretion. This prevents the activation of Wnt ligands, interferes with Wnt-mediated signaling, and inhibits cell growth in Wnt-driven tumors. Porcupine, a membrane-bound O-acyltransferase (MBOAT), is required for the palmitoylation of Wnt ligands, and plays a key role in Wnt ligand secretion and activity. Wnt signaling is dysregulated in a variety of cancers.
Quality Control
H-NMR,C-NMR,LC-MS,HPLC. |
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