Kobe-2602 ID:1648
| Synonyms: |
| CAS NO : 454453-49-7 |
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| Molecular Formula: C14H9F4N5O4S |
| Molecular Weight: 419.31 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks: Kobe2602, is analog of Kobe0065 , is is a potent and selective RAS inhibitor, which exhibit inhibitory activity toward H-Ras GTP-c-Raf-1 binding both in vivo and in vitro. Kobe2602 effectively inhibits both anchorage-dependent and -independent growth and induce apoptosis of H-ras(G12V)-transformed NIH 3T3 cells, which is accompanied by down-regulation of downstream molecules such as MEK/ERK, Akt, and RalA as well as an upstream molecule, Son of sevenless. Moreover, Kobe2602 exhibits antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-ras(G12V) gene by oral administration. Kobe2602 may serve as a scaffold for the development of Ras inhibitors with higher potency and specificity .
Quality Control
H-NMR,C-NMR,LC-MS,HPLC. |
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