Bexagliflozin ID:1605
| Synonyms: |
| CAS NO : 1118567-05-7 |
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| Molecular Formula: C24H29ClO7 |
| Molecular Weight: 464.94 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:Bexagliflozin, also known as EGT1442, is a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. The IC(50) values for EGT1442 against human SGLT1 and SGLT2 are 5.6μM and 2nM, respectively. In normal rats and dogs a saturable urinary glucose excretion was produced with an ED(50) of 0.38 and 0.09mg/kg, respectively. EGT1442 showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients.
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H-NMR,C-NMR,LC-MS,HPLC. |
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