BMS-582949 HCl ID:1570
| Synonyms: |
| CAS NO : 623152-17-0 |
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| Molecular Formula: C22H27ClN6O2 |
| Molecular Weight: 442.948 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor. BMS-582949 is currently under Phase II clinical trials for the treatment of inflammatory diseases. One clinical study showed that, in stable atherosclerosis, 12 weeks of treatment with BMS-582949 did not reduce arterial inflammation or hs-CRP compared to placebo, whereas intensification of statin therapy significantly decreased arterial inflammation. p38α MAP kinase plays a crucial role in regulating the biosynthesis of many inflammatory cytokines including TNFα and IL-1β.
Quality Control
H-NMR,C-NMR,LC-MS,HPLC. |
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